He studied in Switzerland, at the University and Polytechnic of Zurich. He returned to Greece in 1919 and was elected professor of physics at the E.M. Polytechnic. He was also Director of the Physics Laboratories. He also taught at the Higher Agricultural School.

He was multilingual and spoke English, French, Italian, German and Russian. He was a great researcher and inventor in various fields, Statistics, Hydraulics, Natural energy sources, Electromagnetic waves, etc. He became internationally known for his pioneering studies and applications of various qualities of cement he invented (1920-25).

Pavlos Santorini’s brilliant scientific career was internationally recognized and he was recognized as a member and partner of many Academies, such as Toulouse and New York (1961), the Royal Academy of Arts in London (1972) and Honorary President of the Philosophical Congress of Nicosia (1969).

He was awarded with prizes and medals : Fermat Medal from the Academy of Toulouse, Vermeil of Research and Inventions Paris 1968, Vermeil Medal of Progress Paris 1969, etc.By the Kings of Greece, Paul I, George II and Constantine II he was awarded the Order of the Phoenix of George I, etc.